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Symposium I "dermal Toxicology"
Introduction … Masaru ISHIHARA, M.D … 1
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Safety Evaluation of Fragrance Materials … Dr.Opdyke … 3
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Sensitization Test of Laboratory Animals(Open Epicutaneous Test) … Dr.Klecak … 20
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Safety Evaluation of Fragrance Products … Dr.Gressel … 32
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Cosmetic and Toiletry Safety Evaluation in Europe … Dr.Cooke … 43
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Experiences of Animal Study on the Relationship Between Skin Irritation and Systemic Toxicity of Chemicals: Detergents and Pesticides … Ryuta ITO … 57
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The purity of Cosmetic Ingredients and Contact Sensitivity … Takehito KOZUKA … 65
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The Effect of Surfactants on Dermal Toxicity of Chemical Substances … Kikuhiko OKAMOTO, Mitsuo KONDO, Takashi SUNAGAWA … 68
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A Suitable Concentration and Vehicle of Ingredients of Cosmetics in the Diagnostic Patchtest … Tetsuro SUGAI … 75
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Biological Evaluation on Systemic and Local Effects of Topical Corticosteroids Following Percutaneous Absorption … Katsuyuki TAKEDA, Tetsuji ASATO, Masashi NOMOTO, Seiichi AI … 81
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Symposium II "Some Problemes of Percutaneous absorption"
Factors Influencing Skin Penetration of Chemicals … Hiromi OSAMURA, Masaru ISHIHARA … 88
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Percutaneous Absorption in Experimental Animals … Goro URAKUBO … 99
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Effect of Vehicles on Percutaneous Absorption … Mitsunori WASHITAKE … 101
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Autoradiographic Study on Percutaneous Absortion of Cosmetic Ingredients … Masami SUZUKI … 106
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The Absorption Through the Human Skin of External Corticosteroid … Yushi TAKEDA … 119
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Reviews
The Necessity of Patch Test … Ritsuko HAYAKAWA … 126
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GMP for Cosmetics … Katutomo AKAGI … 134
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Prelimenary report
Frequency Distribution of Onset Year in Partients with Pigmented Contact Dermatitis and Causative Agents … Tetsuro SUGAI, Sachiyo YAMAMOTO, Takashi TAKAGI, Yohko TAKAHASHI … 140
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Announcement … 145