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Regular Articles：
The Antioxidant Effect of Novel Ascorbic Acid Derivative 3-O-Glyceryl Ascorbate …Yushi KATSUYAMA, Sayaka NAKAMURA, Norihisa TAIRA, Hitoshi MASAKI, Masato YOSHIOKA … 89
Key words: 3-O-glyceryl ascorbate, antioxidant, high stability of cosmetic formulation, reactive oxygen species, anti-skin
aging.
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Oxidative Stress-Induced Melanogenesis Promotion Mediated by Dermis-Derived Neuregulin 1 （NRG1） …Yuhko MURAKAMI, Hiroaki ADACHI, Hiroshi TANAKA, Youichi YASHIRO, Satoru NAKATA … 95
Key words: neuregulin 1 （NRG1）, dermal-derived factor, fibroblast, melanogenesis, H2O2.
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Seminar
Present Safety Conditions of Cosmetics and Proposals Securing the Safety from the Viewpoint of a Dermatologist … Kayoko MATSUNAGA … 103
Key words: skin safety, cosmetics, hydrolyzed wheat protein, food allergy, cosmetic-induced leukoderma.
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Importance of Skin Penetration and Permeation in Development of Cosmetics …Makiko FUJII … 109
Key words: skin concentration, safty test, formulation.
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Current Practice and Future Directions of Alternative Methods for Safety Assessment … Masaaki MIYAZAWA … 114
Key words: non-animal test methods, safety evaluation, skin sensitization, eye irritation, skin irritation.
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Current State and Future Prospects of Cosmetic and Quasi Drugs … Hiroshi TOKUNAGA … 119
Key words: hydrolyzed wheat powder, food-dependent exercise-induced anaphylaxis, rododendrol, vitiligo.
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Contribution
Progress of Science Leading to the Future of Cosmetics … Tadanori MAYUMI … 126
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Technical Information … 130
Reports on Related Research Meetings … 153
Notice on Related Research Meetings … 156
Announcement … 159